The Evaluation of Surrogate Endpoints (Statistics for Biology and Health) Book PDF, ePub eBook

Join our eBook service for unlimited books & audiobooks. Get a free 7 day subscription! ↓↓↓↓↓


Book Descriptions:
Both humanitarian and commercial considerations have spurred intensive search for methods to reduce the time and cost required to develop new therapies. The identification and use of surrogate endpoints, i.e., measures that can replace or supplement other endpoints in evaluations of experimental treatments or other interventions, is a general strategy that has stimulated both enthusiasm and skepticism. Surrogate endpoints are useful when they can be measured earlier, more conveniently, or more frequently than the 'true' endpoints of primary interest. Regulatory agencies around the globe, particularly in the United States, Europe, and Japan, are introducing provisions and policies relating to the use of surrogate endpoints in registration studies. But how can one establish the adequacy of a surrogate? What kind of evidence is needed, and what statistical methods portray that evidence most appropriately? This book offers a balanced account on this controversial topic. The text presents major developments of the last couple of decades, together with a unified, meta-analytic framework within which surrogates can be evaluated from several angles. Methodological development is coupled with perspectives on various therapeutic areas. Academic views are juxtaposed with standpoints of scientists working in the biopharmaceutical industry as well as of colleagues from the regulatory authorities. Tomasz Burzykowski is Assistant Professor of Biostatistics at the Limburgs Universitair Centrum in Belgium. Dr. Burzykowski has published methodological work on the analysis of survey data, meta-analyses of clinical trials, and validation of surrogate endpoints. He is a co-author of numerous papers applying statistical methods to clinical data in different disease areas (cancer, cardiovascular diseases, dermatology, orthodontics). Geert Molenberghs is Professor of Biostatistics at the Limburgs Universitair Centrum in Belgium. Dr. Molenberghs published methodological work on surrogate markers in clinical trials, categorical data, longitudinal data analysis, and on the analysis of non-response in clinical and epidemiological studies. He serves as Joint Editor for Applied Statistics (2001-2004) and is President of the International Biometric Society (2004-2005). He was elected Fellow of the American Statistical Association and received the Guy Medal in Bronze from the Royal Statistical Society. Marc Buyse founded the International Drug Development Institute in 1991. He is Past President of the International Society for Clinical Biostatistics, Past President of the Quetelet Society, and Past Board Member of the Society for Clinical Trials. He is currently the Executive Director of IDDI (International Drug Development Institute) and Associate Professor of biostatistics at the Limburgs Universitair Centrum, Center for Statistics, Diepenbeek, Belgium. He has published extensively in the fields of biostatistics and oncology. His research interests include meta-analysis, surrogate endpoints, statistical detection of fraud, and the design and statistical analysis of clinical trials. From the reviews: 'A strength of this book is its comprehensive and up-to-date presentation of issues pertinent to the evaluation of surrgoate endpoints...This book makes an important contribution to the clinical trials literature...' Journal of Biopharmaceutical Statistics, 2006 'Many of the chapters deal with real-life data examples and studies involving surrogate outcomes, many written by authors who were directly involved in these studies...The editors have written nice background sections...until a more concise manuscript on this topic is written, this book will remain the most important resource for biostatisticians and researchers in this area.' Debajyoti Sinha for the Journal of the

The Evaluation of Surrogate Endpoints (Statistics for Biology and Health) by Tomasz Burzykowski, Geert Molenberghs, Marc Buyse

From reader reviews:

Velda Thornley:

Have you spare time to get a day? What do you do when you have a lot more or little spare time? That's why, you can choose the suitable activity intended for spend your time. Any person spent their own spare time to take a stroll, shopping, or went to typically the Mall. How about open or even read a book called The Evaluation of Surrogate Endpoints (Statistics for Biology and Health)? Maybe it is being best activity for you. You recognize beside you can spend your time using your favorite's book, you can better than before. Do you agree with the opinion or you have some other opinion?

Adria Jenkins:

This The Evaluation of Surrogate Endpoints (Statistics for Biology and Health) is new way for you who has attention to look for some information mainly because it relief your hunger of information. Getting deeper you upon it getting knowledge more you know or else you who still having little digest in reading this The Evaluation of Surrogate Endpoints (Statistics for Biology and Health) can be the light food for yourself because the information inside this particular book is easy to get by anyone. These books produce itself in the form and that is reachable by anyone, yeah I mean in the e-book type. People who think that in reserve form make them feel drowsy even dizzy this guide is the answer. So you cannot find any in reading a book especially this one. You can find what you are looking for. It should be here for a person. So , don't miss it! Just read this e-book variety for your better life along with knowledge.

Conrad Degregorio:

On this era which is the greater individual or who has ability in doing something more are more precious than other. Do you want to become considered one of it? It is just simple approach to have that. What you have to do is just spending your time not very much but quite enough to possess a look at some books. One of several books in the top checklist in your reading list is definitely The Evaluation of Surrogate Endpoints (Statistics for Biology and Health). This book which is qualified as The Hungry Hillsides can get you closer in turning into precious person. By looking right up and review this publication you can get many advantages.

Silvia Doucet:

You can get this The Evaluation of Surrogate Endpoints (Statistics for Biology and Health) by look at the bookstore or Mall. Just viewing or reviewing it can to be your solve trouble if you get difficulties to your knowledge. Kinds of this publication are various. Not only by means of written or printed but also can you enjoy this book by means of e-book. In the modern era just like now, you just looking by your mobile phone and searching what their problem. Right now, choose your current ways to get more information about your publication. It is most important to arrange you to ultimately make your knowledge are still upgrade. Let's try to choose right ways for you.